帕罗西汀联合认知行为疗法治疗强迫症的对照研究
2022-06-09
【论文摘要】 目的：探讨帕罗西汀联合认知行为疗法治疗强迫症的临床疗效。方法：选取本院2014年1月-2015年3月收治的90例强迫症患者作为研究对象，采用随机 数字表法将其分为治疗组和对照组，每组45例，对照组给予帕罗西汀治疗，治疗组给予帕罗西汀联合认知行为疗法治疗。分别在治疗后1、3、6个月使用 Yale-Brown强迫量表（Y-BOCS）和自我和谐量表（SCCS）评估两组的治疗效果，比较两组治疗效果及不良反应发生情况。结果：治疗后1、 3、6个月，治疗组Y-BOCS及SCCS评分均优于对照组，比较差异均有统计学意义（P<0.05）；两组均未出现严重不良反应，两组总不良反应 发生率比较，差异无统计学意义（P>0.05）。结论：帕罗西汀联合认知疗法治疗强迫症疗效显著，优于单一使用帕罗西汀的纯药物疗法，且不良反应 少，值得临床推广使用。
【论文关键词】 帕罗西汀； 认知行为疗法； 强迫症
【Abstract】 Objective：To investigate the clinical efficacy of Paroxetine combined with cognitive behavior treatment for patients with obsessive compulsive disorder.Method：90 cases of obsessive compulsive disorder patients in our hospital from January 2014 to March 2015 were selected and randomly divided into control group and treatment group，with 45 cases in each group.The control group received Paroxetine for treatment.The treatment group received Paroxetine combined with cognitive behavior treatment.1，3 and 6 months after treatment，the clinical efficacy of the two groups were evaluated by Y-BOCS and SCCS.The clinical efficacy and incidence of adverse reactions were compared between the two groups.Result：1，3 and 6 months after treatment，the Y-BOCS and SCCS scores of the treatment group were better than those of the control group，the differences were statistically significant（P<0.05）.No serious adverse reactions occurred in both groups.There was no statistically significant difference in the incidence of adverse reactions between the two groups（P>0.05）.Conclusion：Paroxetine combined with cognitive behavior treatment has exact effect for obsessive compulsive disorder，which is better than the single use of Paroxetine.It has little adverse reactions and is worthy of widely using in clinic.
【Key words】 Paroxetine； Cognitive behavior treatment； Obsessive compulsive disorder
强迫症患者一般无法控制自己的强迫思维或强迫行为，该病多发生在青春期，患者的日常生活受到严重影响，且病程迁延，预后较差，致残率高 [1-2]。临床对于该病的治疗多以药物治疗为主，但疗效欠佳[3]。如何提高强迫症患者的治疗效果受到越来越多的研究者关注，近年来提出的药物联合认知 行为疗法成为提高强迫症疗效的研究热点，认知行为疗法在帮助患者发现并分析内心的矛盾冲突、学会解决问题、重塑健全人格方面效果显著，而该疗法与传统疗法 的对照研究较少，本研究以本院收治的90例强迫症患者为研究对象，旨在探讨帕罗西汀联合认知行为疗法治疗强迫症的临床效果，现报道如下。
1 资料与方法
1.1 一般资料 选取本院2014年1月-2015年3月收治的90例强迫症患者作为研究对象，所选患者均符合ICD-10（精神与行为障碍分类）中关于强迫症的诊断标准 [4]；Yale-Brown强迫量表得分≥16分；患者签署知情同意书；排除存在器质性病变和严重躯体疾病等的患者。将90例强迫症患者采用随机数字表 法均分为治疗组和对照组。对照组中男23例，女22例，年龄
【论文关键词】 帕罗西汀； 认知行为疗法； 强迫症
【Abstract】 Objective：To investigate the clinical efficacy of Paroxetine combined with cognitive behavior treatment for patients with obsessive compulsive disorder.Method：90 cases of obsessive compulsive disorder patients in our hospital from January 2014 to March 2015 were selected and randomly divided into control group and treatment group，with 45 cases in each group.The control group received Paroxetine for treatment.The treatment group received Paroxetine combined with cognitive behavior treatment.1，3 and 6 months after treatment，the clinical efficacy of the two groups were evaluated by Y-BOCS and SCCS.The clinical efficacy and incidence of adverse reactions were compared between the two groups.Result：1，3 and 6 months after treatment，the Y-BOCS and SCCS scores of the treatment group were better than those of the control group，the differences were statistically significant（P<0.05）.No serious adverse reactions occurred in both groups.There was no statistically significant difference in the incidence of adverse reactions between the two groups（P>0.05）.Conclusion：Paroxetine combined with cognitive behavior treatment has exact effect for obsessive compulsive disorder，which is better than the single use of Paroxetine.It has little adverse reactions and is worthy of widely using in clinic.
【Key words】 Paroxetine； Cognitive behavior treatment； Obsessive compulsive disorder
强迫症患者一般无法控制自己的强迫思维或强迫行为，该病多发生在青春期，患者的日常生活受到严重影响，且病程迁延，预后较差，致残率高 [1-2]。临床对于该病的治疗多以药物治疗为主，但疗效欠佳[3]。如何提高强迫症患者的治疗效果受到越来越多的研究者关注，近年来提出的药物联合认知 行为疗法成为提高强迫症疗效的研究热点，认知行为疗法在帮助患者发现并分析内心的矛盾冲突、学会解决问题、重塑健全人格方面效果显著，而该疗法与传统疗法 的对照研究较少，本研究以本院收治的90例强迫症患者为研究对象，旨在探讨帕罗西汀联合认知行为疗法治疗强迫症的临床效果，现报道如下。
1 资料与方法
1.1 一般资料 选取本院2014年1月-2015年3月收治的90例强迫症患者作为研究对象，所选患者均符合ICD-10（精神与行为障碍分类）中关于强迫症的诊断标准 [4]；Yale-Brown强迫量表得分≥16分；患者签署知情同意书；排除存在器质性病变和严重躯体疾病等的患者。将90例强迫症患者采用随机数字表 法均分为治疗组和对照组。对照组中男23例，女22例，年龄